What requirement was established due to fatal poisoning from liquid sulfanilamide?

The correct response to the question is based on the historical context surrounding the regulation of pharmaceuticals and the events that prompted legislative changes in the United States. The fatal poisoning incidents resulting from liquid sulfanilamide in 1937 raised significant concerns about drug safety and the responsibility of manufacturers to ensure the safety and efficacy of their products.

As a direct response to the tragedy associated with sulfanilamide, the Food, Drug, and Cosmetic Act of 1938 was enacted. This law introduced comprehensive regulations requiring that drugs be proven safe for use before they could be marketed. It mandated pre-market approval of new drugs by the FDA, fundamentally shifting the landscape of pharmaceutical regulation and establishing a framework for ongoing safety assessments.

The establishment of this act also led to a greater emphasis on label accuracy and the need for manufacturers to provide adequate warnings about potential risks associated with their products. This overhaul was critical in enhancing consumer protection and ensuring that medication, especially new drugs entering the market, underwent rigorous scrutiny to prevent future occurrences of unsafe products.

The other options correspond to different regulatory milestones, but they do not capture the immediate legislative action taken in response to sulfanilamide's dangerous effects. The Durham-Humphrey Amendment primarily focused on the distinction between prescription and over