What happens to drugs when they form complexes with other molecules?

When drugs form complexes with other molecules, they may become inactive. This process occurs when the drug binds to another substance, which can affect its pharmacological activity. Such complex formation can hinder the drug's ability to interact with its target, such as receptors or enzymes, thereby preventing it from eliciting its intended therapeutic effect.

For example, drug complexes can form with proteins, other drugs, or even inactive substances, which often leads to a reduction in the free concentration of the active drug in circulation. This reduction results in diminished efficacy as the drug is rendered unavailable to exert its therapeutic action.

Understanding this process is crucial for pharmacy technicians when considering drug interactions and the overall effectiveness of a patient's medication regimen. In clinical practice, this knowledge helps professionals anticipate potential issues with drug efficacy and guide proper dosing adjustments or alternative therapies as needed.