If enterohepatic cycling does not occur, which route can drugs be excreted through?

When enterohepatic cycling does not occur, drugs can be excreted through bile. Enterohepatic cycling is a process that involves the reabsorption of drugs from the intestines back into the bloodstream after they've been secreted into the bile. If this process is interrupted or does not happen, the drugs can still be eliminated from the body through bile, which is eventually excreted in the feces.

This route of excretion minimizes the drug's presence in systemic circulation and contributes to the overall elimination of pharmacologically active compounds. Bile serves as a transport medium for larger molecules, such as certain drugs and their metabolites, thereby ensuring that they are removed from the body efficiently.

In contrast, the other routes mentioned do not serve as a primary means for drug excretion in this context. Blood is primarily a transport medium for nutrients, gases, and hormones rather than an excretion pathway. Gastric acid plays a role in the digestion of food and does not participate in drug excretion. Enzymes are involved in metabolism and chemical reactions but do not directly excrete drugs. Therefore, the correct answer focuses on the role of bile in drug elimination when enterohepatic cycling is not taking place.